Effective and flexible delivery of important biomedical molecule

PhD defence, Friday December 7, 2018. Anna Kaastrup Winther.

2018.12.07 | Olivia Elsebeth Belling-Nami

Anna Kaastrup Winther.

During her studies, MSc Anna Kaastrup Winther investigated a system for local generation of the gaseous molecule nitric oxide (NO). This molecule is involved in multiple functions in both healthy and diseased tissue in the body, making it highly relevant as a therapeutic. However, its gaseous nature makes it extremely difficult to administer. By inserting enzymes into implantable biomaterials, Anna Kaastrup Winther succeeded in generating NO locally by on-site enzymatic activation of deactivated drugs in a highly controllable manner. In addition, Anna Kaastrup Winther investigated the potential of nanomaterials to replace the enzyme used in this system.

These findings establish a highly flexible method for local delivery of gaseous molecules in treatment of various diseases.

The PhD degree was completed at the Department of Chemistry, Science and Technology, Aarhus University.

This résumé was prepared by the PhD student.

Time: Friday December 7, 2018 at 13.30.
Place: Building 1531, room 119, Auditorium D2, Department of Mathematics, Ny Munkegade 120, Aarhus University, 8000 Aarhus C.
Title of PhD thesis: Enzyme prodrug therapy for generation of nitric oxide
Contact information: Anna Kaastrup Winther, e-mail: annawinther@chem.au.dk, tel.: +45 20856125

Members of the assessment committee:
Professor Carmen Alvarez-Lorenzo, Department of Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela, Spain
Professor John Nielsen, Department of Drug Design and Pharmacology, University of Copenhagen, Denmark
Professor Steen Uttrup Pedersen (chair), Department of Chemistry, Aarhus University
Main supervisor:
Associate professor Alexander N. Zelikin, Department of Chemistry and Interdisciplinary Nanoscience Center (iNANO), Science and Technology, Aarhus University
Language: The PhD thesis will be defended in English

The defence is public.
The dissertation is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1520 and 1521, 8000 Aarhus C.

PhD defence
12183 / i43