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Characterisation of how the protein involved in Parkinson’s disease changes from normal to pathogenic

PhD defence, Monday 17 February 2020, Anne Louise Grønnemose.

2020.02.17 | Mie Meulengracht Christensen

Anne Louise Grønnemose

During her PhD studies, Anne Louise Grønnemose researched a protein – called alpha-synuclein – which is present in human brains. All humans have this protein; however, its structure can change so it suddenly can aggregate and yield protein accumulations and this causes Parkinson’s disease. The focus for this PhD has been to characterize how this protein changes from normal to pathogenic. The achieved research results contribute to the understanding of how Parkinson’s disease arise as a result of the change in this protein.

The PhD degree was completed at the Interdisciplinary Nanoscience Center (iNANO), Faculty of Natural Sciences, Aarhus University.

This résumé was prepared by the PhD student.







Time:
Monday, 17 February 2020 at 13.15
Place: Building 1590, room 213, iNANO, Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C.
Title of PhD thesis: Characterisation of oligomers of α-synuclein by hydrogen/deuterium exchange monitored by mass spectrometry
Contact information: Anne Louise Grønnemose, e-mail: annelouisehemdrup@gmail.com, tel.: +45 2815 3767
Members of the assessment committee:
Group leader, PhD Natàlia Carulla, Institute Européen de Chimie et Biologie (IECB) et CBMN (UMR 5248), University of Bordeaux – CNRS – INP Bordeaux, Pessac, France
Group Leader and Professor, PhD Kasper Dyrberg Rand, Protein Analysis Lab, Department of Pharmacy, Analytical Biosciences, University of Copenhagen
Associate Professor Alexander N. Zelikin (chair), iNANO and Department of Chemistry, Aarhus University
Main supervisor:
Professor Daniel E. Otzen, iNANO and Department of Molecular Biology and Genetics, Aarhus University
Co-supervisor:
Associate Professor Thomas J. D. Jørgensen, Department of Biochemistry and Molecular Biology, University of Southern Denmark


Language:
The PhD dissertation will be defended in English

The defence is public.
The PhD thesis is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1521, 8000 Aarhus C.

PhD defence
12183 / i43