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Characterising Site-Specific Binding to Albumin, a Natural Drug Carrier in Circulation

PhD defence, Friday 29 May 2020. Malene Selch Sønnichsen.

2020.05.29 | Mie Meulengracht Christensen

Malene Selch Sønnichsen

During her PhD studies, Malene Selch Sønnichsen has established a platform for characterising binding of molecules to albumin protein in a site-specific manner, using nuclear magnetic resonance. Albumin is a natural carrier of a variety of molecules in the blood circulatory system, and her research will contribute to the understanding of the pharmacokinetic properties of drug delivery.

The PhD study was completed at Interdisciplinary Nanoscience Center iNANO, Faculty of Natural Sciences, Aarhus University, in collaboration with Novo Nordisk and funded by the Innovation Fund Denmark .

This summary was prepared by the PhD student.

Time: Friday, 29 May 2020 at 13:00
Place: The PhD defence will be held online.
To receive a link to the event, please send an e-mail to Jan Skov Pedersen, jsp@chem.au.dk
Title of PhD thesis: Development of a Site-Specific Albumin-Binding Assay
Contact information: Malene Selch Sønnichsen, e-mail: malene001@hotmail.com

Members of the assessment committee:
Professor Dr. Gregg Siegal, Faculty of Science, Chemistry and Pharmaceutical Sciences, Free University of Amsterdam, The Netherlands
Associate Professor Dr. Kaare Teilum, Department of Biology, University of Copenhagen, Denmark
Professor Jan Skov Pedersen (chairman), iNANO and Department of Chemistry, Aarhus University, Denmark
Main supervisor:
Associate Professor Dr. Frans A. A. Mulder, iNANO and Department of Chemistry, Aarhus University, Denmark
Co-supervisors:
Senior Research Scientist Marie Ø. Pedersen, Department of Biophysics and Injectable Formulation 2, Novo Nordisk, Denmark
Principal Scientist Fredrik Kryh Öberg, Department of Recombinant Diversity Technologies, Novo Nordisk, Denmark

Language: The PhD dissertation will be defended in English

The defence is public.

Due to the coronavirus situation, Aarhus University is physically closed. Therefore, the PhD thesis will not be available for reading at the offices of the PhD administration. Instead, interested parties may send an e-mail to gradschool.scitech@au.dk, and receive a digital copy of the PhD thesis. Please note, it may in certain cases be necessary to make an individual arrangement to read the PhD thesis.

PhD defence
12183 / i43