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From a Toxic Gas to Pharmaceuticals

PhD defence, Friday 27 March 2020, Katrine Domino.

2020.03.27 | Mie Meulengracht Christensen

Katrine Domino

During her PhD studies, Katrine Domino researched the application of the gas carbon monoxide as a building block in organic synthesis. The emphasis has been on the development of new methods for synthesis of fluorine-containing molecules using the transition metal palladium as a catalyst to promote the desired chemical reactivity. Formation of fluorine-containing compounds is of significance to the development of pharmaceuticals and materials, as strategic placement of fluorine can be used to fine-tune the physical and chemical properties of a molecule. Additionally, Katrine has investigated the use of ruthenium for the reduction of CO2 to carbon monoxide with the aim of utilizing CO2 as a valuable C1 building block in organic synthesis.

The new research findings contribute to a better understanding of the interplay between palladium and fluorinated reagents and have resulted in the development of new protocols for synthesis of pharmaceutically relevant organic functionalities.

The PhD study was completed at the Interdisciplinary Nanoscience Center (iNANO), Faculty of Natural Sciences, Aarhus University.

This summary was prepared by the PhD student.

Time: Friday, 27 March 2020 at 13.15
Place: Will be held online    
Title of PhD thesis: New Advances in Transition Metal Catalyzed Reactions using Gaseous- and Fluorinated Building Blocks
Contact information: Katrine Domino, e-mail: domino@inano.au.dk, tel.: +45 26252009
Members of the assessment committee:
Professor Lukas Goossen, Department of Chemistry and Biochemistry – Organic Chemistry, Ruhr Universität Bochum, Germany
Professor Mogens Brøndsted Nielsen, Department of Chemistry, University of Copenhagen, Denmark
Associate Professor Alexander N. Zelikin (chairman), iNANO and Department of Chemistry, Aarhus University, Denmark
Main supervisor:
Professor Troels Skrydstrup, iNANO and Department of Chemistry, Aarhus University, Denmark
Co-supervisor:
Professor Kim Daasbjerg, iNANO and Department of Chemistry, Aarhus University, Denmark

Language: The PhD dissertation will be defended in English

The defence is public.

The PhD thesis is available for reading at the Graduate School of Science and Technology/GSST,
Ny Munkegade 120, building 1521, 8000 Aarhus C.

PhD defence
12183 / i43