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Simulations of the interactions between amylin and cell membranes – a mechanism in Type-II Diabetes

PhD defense, Wednesday 8 January 2020. Mikkel Hovden Christensen.

2020.01.08 | Mie Meulengracht Christensen

Mikkel Hovden Christensen

During his studies, Mikkel H. Christensen, M.Sc., researched a peptide which worsens the conditions for patients with type-II diabetes. The peptides is known as islet amyloid polypeptide or amylin, and the healthy individuals it regulates the uptake of sugars together with insulin. In patients with type-II diabetes, amylin accumulates on the beta-cells and form cytotoxic fibril in the pancreas, which deteriorate the disease.

Mikkel has investigated how amylin interacts with cell-membranes and how the peptides interaction with the membrane is affected by the lipids in the membrane. The investigations have been performed using molecular simulations, which allows studies of the molecules in atomistic detail.

The PhD degree was completed at the Interdisciplinary Nanoscience Center (iNANO), Science and Technology, Aarhus University.

This résumé was prepared by the PhD student.

Wednesday 8 January 2020 at 13.15
Place: Building 1593, room 012, iNANO Auditorium, Interdisciplinary Nanoscience Center (iNANO), Aarhus University
Title of PhD thesis: Computational studies of the membrane interactions of the islet amyloid polypeptide
Contact information: Mikkel Hovden Christensen, e-mail: mhc@clin.au.dk, Phone: +45 30202472

Members of the assessment committee:
Professor Kresten Lindorff-Larsen, Department of Biology, University of Copenhagen, DK
Reader Martin Ulmschneider, Department of Chemistry, King’s College London, UK
Professor Troels Skrydstrup, iNANO and Department of Chemistry, Aarhus University (chair)
Main supervisor:
Professor Birgit Schiøtt, Department of Chemistry and iNANO, Aarhus University

Language: The PhD dissertation will be defended in English

The defence is public.
The PhD thesis is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1521, 8000 Aarhus C    

PhD defence
12183 / i43