Aarhus University Seal / Aarhus Universitets segl

Understanding the Regulatory Mechanism of a Calcium Transporter

PhD defence, Monday 20 January 2020. Sigrid Thirup Larsen.

2020.01.20 | Mie Meulengracht Christensen

Sigrid Thirup Larsen

During her Ph.D. studies, Sigrid Thirup Larsen researched the regulatory mechanism of the Plasma membrane calcium ATPase, a protein that transports calcium.  Located in the plasma membrane of eukaryotic cells the plasma membrane calcium ATPase transport calcium across the membrane and out of the cell against a 20.000 fold steep calcium gradient. The protein is important for calcium signaling, which control processes such as muscle contractions, learning and memory. Sigrid Thirup Larsen has studied the plasma membrane calcium ATPase, ACA8 from the plant Arabidobsis thaliana as well as the human plasma membrane calcium ATPases. The goal has been to obtain a deeper understanding of the regulatory mechanisms that govern calcium transport.

The research has led to a better understanding of how the plasma membrane calcium ATPases are regulated and has increased our current knowledge of their role in the very intricate system of calcium signaling.  

The PhD degree was completed at the Interdisciplinary Nanoscience Center (iNANO), Science and Technology, Aarhus University.

This résumé was prepared by the PhD student.

Time: Monday 20 January 2020 at 13:15
Place: Building 1534, room 125, Auditorium F, Department of Physics and Astronomy, Aarhus University, Ny Munkegade 118, 8000 Aarhus C
Title of PhD thesis: Activity and Regulation of Plasma Membrane Calcium ATPases – Functional and Structural Characterisation
Contact information: Sigrid Thirup Larsen, e-mail: sigrid89@inano.au.dk, tel.: +45 29417210

Members of the assessment committee:
Professor Jens Preben Morth, Department of Biotechnology and Biomedicine, Technical University of Denmark
Professor Emanuel E. Strehler, Department of Biochemistry & Molecular Biology, Mayo Clinic - Rochester
Professor Jørgen Kjems, iNANO and Department of Molecular Biology and Genetics, Aarhus University (chair) 

Main supervisor:
Professor Poul Nissen, Department of Molecular Biology and Genetics, Aarhus University

Language: The PhD dissertation will be defended in English

The defence is public.
The PhD thesis is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1521, 8000 Aarhus C.

PhD defence
12183 / i43