Aarhus University Seal / Aarhus Universitets segl

Development of novel 3D bioactive scaffolds-giving promise for accelerating peripheral neural regeneration

PhD defense, Monday 18 November 2019. Zhongyang Zhang.

2019.11.18 | Mie Meulengracht Christensen

Zhongyang Zhang

Peripheral nerve injuries (e.g. brachial plexus injury, peroneal nerve injury etc.) constitute a major proportion of nervous system diseases, which lead to neuron loss and/or neurite damage. For repairing large injuries (typically >20 mm), autologous nerve graft is the golden standard. But this therapy might be hindered by several limitations including higher risk of infection and extra pain during multiple surgeries, functional loss and limited availability of the donor nerve etc. During his/her studies, Zhongyang developed novel 3D bioscaffolds for constructing artificial nerve guidance conduit (NGCs), as substitute for the autologous nerve graft. By introducing well-defined non-biochemical factors, the neural regeneration on the scaffolds is guided and accelerated along specific direction under remote light-irradiation. Zhongyang further explored how the scaffolds can be assembled into NGCs for clinical application.

The new research findings contribute to the design of efficient NGCs for repairing peripheral nerve injuries. The combination of commonly used biochemical/cellular therapy and proposed non-biochemical factors gives great potential for promoting the regeneration efficiency.

The PhD degree was completed at the Interdisciplinary Nanoscience Center (iNANO), Science and Technology, Aarhus University.

This résumé was prepared by the PhD student.

Time: Monday 18 November 2019 at 13:15
Place: Building 1534, room 125, Auditorium F, Department of Mathematics, Aarhus University
Title of PhD thesis: 3D Bioactive Scaffolds with Synergistic Non-biochemical Cues for Peripheral Neural Regeneration
Contact information: Zhongyang Zhang, e-mail: zhongyang@inano.au.dk, tel.: +45 52742508

Members of the assessment committee:
Professor Adam Perriman, School of Cellular Medicine, University of Bristol, UK
Associate Professor Bozhi Tian, The James Franck Institute, The University of Chicago, USA
Professor Liv Hornekær (chair), iNANO and Department of Physics and Astronomy, Aarhus University
Main supervisor:
Associate Professor Menglin Chen, iNANO and Department of Engineering, Aarhus University
Associate Professor Mingdong Dong, iNANO, Aarhus University

Language: The PhD dissertation will be defended in English

The defence is public.
The PhD thesis is available for reading at the Graduate School of Science and Technology/GSST, Ny Munkegade 120, building 1521, 8000 Aarhus C.

PhD defence
12183 / i43